Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Villa in Portobelo
Entire Villa with pool in front of beach!
Villa in Panamá
Beautiful House in Panama w/ King Beds + Pool
Villa in Panamá
Breathtaking Views Mansion w/King Beds
Condo in San Carlos District
Punta Caelo Beach Front View
Home in Río Hato
Spectacular beachfront house in Buenaventura!
Home in Río Hato
Renewed / Make yourself at Home / Enjoy
Villa in Buenaventura, El Chirú
Lake House | Pool | King Beds | Next to Beach Club
Villa in Playa Venao
Casa Aqua: Amazing beach front house - Playa Venao
Luxury mansion rentals
Home in Panamá
Unique 4 room house - direct access to the beach
Villa in Punta Chame
FREE NIGHT Amazing Beachfront Villa - Palm House
Rental unit in Maria Chiquita
Spacious 4Br Beachside Getaway at Playa Escondida
Villa in Bejuco
Beach house in Punta Chame, Villa frente al mar
Villa in Río Hato
Secluded Villa in Buenaventura Golf and Resort
Rental unit in Maria Chiquita
Penthouse in Playa Escondida 4 bedrooms
Villa in Río Hato
(Panama) Beach house with golf course.
Villa in Panamá
Incredible Hacienda with ocean and river View
Pet-friendly mansion rentals
Home in Panamá
Wonderful House with Terrace and Sea View
Rental unit in El Chirú
Buenaventura Golf & Beach Resort Lux Apartment
Villa in Bocas del Toro
Casa del Mar - eco aqua villa
Home in San José
αlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Home in Gamboa
BirdHouse@ Gamboa Panamá Canal
Villa in Costa Esmeralda
#1 Villa with pool, jacuzzi, pool table, ping pong.
Home in Pedasí
Ocean View From The Jungle!
Villa in Costa Esmeralda
Spectacular 600-meter oceanfront beach house
Destinations to explore
- Private suite rentals Panama
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- Cottage rentals Panama
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- Monthly Rentals Panama
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- Bed and breakfasts Panama
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- Rentals with a sauna Panama
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- Waterfront rentals Panama
- Island rentals Panama
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- Bungalow rentals Panama
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- Rentals with a kayak Panama
- Rentals with pools Panama
- Rentals with lake access Panama
- Kid-friendly rentals Panama
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- Rentals with a hot tub Panama
- Wheelchair accessible rentals Panama
- House rentals Panama
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- Family travel hub Tips and inspiration
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- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes